Amazing Spider-Man #1000 Preview Reveals Aunt May's Tragic Fate Following Recent Stroke

Amazing Spider-Man #1000 Preview Reveals Aunt May's Tragic Fate Following Recent Stroke

Amazing Spider-Man #1000, the biggest issue in Spider-Man history, hits stands on September 30. Today, you can read an early preview of the landmark issue's lead story by Joe Kelly and Pepe Larraz.

By JoshWilding - Sep 11, 2026 04:09 AM EST
Filed Under: Marvel Comics

In last week's Amazing Spider-Man #35/#999, Spider-Man learned that Aunt May had been rushed to the hospital after suffering a stroke. With that, the stage has been set for Amazing Spider-Man #1000 on September 30.

"Destined to take its place in comic book history," as Marvel Comics puts it, the epic milestone issue marks a major turning point in Joe Kelly and Pepe Larraz's acclaimed run with a pulse-pounding lead story that delivers the shocking fate of Aunt May and sets the stage for a revelatory showdown with the all-new supervillain Ravage.

Today, you can see Spider-Man race to Aunt May's side in a special preview that will also be featured in the back of select Marvel releases hitting stands over the next few weeks. Tragically, as Peter reunites with May and his newfound cousin, Cormac, the hero learns that his Aunt no longer remembers who he is. 

Following Kelly and Larraz's story, Amazing Spider-Man #1000 features an incredible lineup of anniversary stories from superstar creators celebrating Spider-Man's legacy, including definitive creators from Spider-Man history and acclaimed creators contributing to the Spidey mythos for the first time, as well as WWE Hall of Famer & Chief Content Officer Paul "Triple H" Levesque.

Here's a full breakdown of what to expect from the landmark issue:

  • "Still Standing" by Noah Hawley and Patrick Gleason
  • "Requiem for a Goblin" by J.M. DeMatteis and Humberto Ramos
  • "Tears of the Spider-Queen" by Frank Miller and Peach Momoko
  • "The Big Night" by Triple H and Ed McGuinness
  • "The Gesture" by Brian Michael Bendis and Stuart Immonen
  • "Of Webs and Six-Guns" by Larry Lieber and Giuseppe Camuncoli
  • "I Can Never Rest" by Dan Slott and Marcos Martin
  • And more, including an interview with actor Tom Holland and Spider-Man: Brand New Day director Destin Daniel Cretton!

Three weeks out from launch, more than 400,000 copies of Amazing Spider-Man #1000 have been ordered, and a second printing is already in the works.

Following its highly anticipated release on September 30, the issue will return to stores on October 28 with special sketch covers of John Romita Jr. and Pepe Larraz's already-iconic main covers.

Check out this first look inside Amazing Spider-Man #1000 below.

ASM1000 PreviewA

ASM1000 PreviewB

ASM1000 PreviewC

ASM1000 PreviewD

ASM1000 JrJr SecondPrinting

ASM1000 Larraz SecondPrinting

AMAZING SPIDER-MAN #1000
Written by JOE KELLY, NOAH HAWLEY, FRANK MILLER, DAN SLOTT, J.M. DEMATTEIS, BRIAN MICHAEL BENDIS, TRIPLE H, ROB FEE & LARRY LIEBER
Art by PEPE LARRAZ, PATRICK GLEASON, PEACH MOMOKO, MARCOS MARTIN, HUMBERTO RAMOS, STUART IMMONEN, ED MCGUINNESS & GIUSEPPE CAMUNCOLI
Cover by JOHN ROMITA JR. & PAOLO RIVERA
Cover by PEPE LARRAZ
On Sale 9/30

About The Author:
JoshWilding
Member Since 3/13/2009
A lifelong comic book fan who grew up on Spider-Man: The Animated Series in the '90s, Josh Wilding has been contributing to ComicBookMovie.com since 2009.

While he's also written for websites like Batman-News, HeyUGuys, and WhatCulture, Josh is CBM's Rotten Tomatoes-approved critic and the site's #1 contributor with nearly two decades of experience covering film and TV news (including interviews with Tom Holland, Chris Pratt, Gary Oldman, Halle Berry, Jon Bernthal, Tom Welling, and hundreds more).

Based in the UK with his wife, Josh is also an avid WWE and Formula 1 fan and writes about those passions on CBM's sister sites, TheRingReport.com and FullThrottleHQ.com. Favourite superhero? Spider-Man. Favourite pro wrestler? CM Punk. Favourite F1 driver? Max Verstappen.
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Snorterism
Snorterism - 9/11/2026, 4:56 AM
LET ME GUESS.
AUNT MAY BECOME THE NEXT VENOM.

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